abstract：:Cell-cell fusion is central for sexual reproduction, and generally involves gametes of different shapes and sizes. In walled fission yeast Schizosaccharomyces pombe, the fusion of h+ and h- isogametes requires the fusion focus, an actin structure that concentrates glucanase-containing vesicles for cell wall digestion....

authors： Muriel O,Michon L,Kukulski W,Martin SG

更新日期：2021-10-04 00:00:00

abstract：:Intracellular transport in neurons is driven by molecular motors that carry many different cargos along cytoskeletal tracks in axons and dendrites. Identifying how motors interact with specific types of transport vesicles has been challenging. Here, we use engineered motors and cargo adaptors to systematically investi...

authors： Hummel JJA,Hoogenraad CC

更新日期：2021-10-04 00:00:00

abstract：:Toxicarioside G (TCG), a natural product isolated from Calotropis gigantea, has been found to exhibit potent anticancer effects. The present study aimed to investigate the effect of TCG on the SW480 colorectal cancer cell line and the role of autophagy and Yes1 associated transcriptional regulator (YAP) in the TCG‑med...

authors： Zhou L,Wang J,Liu J,Liang J,Wang Y,Cai Q,Huang Y

更新日期：2021-10-01 00:00:00

abstract：:In patients with Parkinson's disease (PD), gastrointestinal dysfunction occurs from the early stages of the disease and even in the pre-motor phase. This condition can include the entire digestive tract, with symptoms ranging from delays in gastric emptying to dysphagia, constipation and even malnutrition. Excess sali...

authors： Ivan IF,Irincu VL,Diaconu Ș,Falup-Pecurariu O,Ciopleiaș B,Falup-Pecurariu C

更新日期：2021-10-01 00:00:00

abstract：:Nitrogen 6-methyladenosine (m6A) is the result of methylation of nitrogen-6 on adenosine, and is the most abundant chemical modification of eukaryotic mRNA. Dysregulation of m6A methylation has been implicated in cancer development and progression through various mechanisms. This type of methylation is primarily regul...

authors： Wen J,Zhang G,Meng Y,Zhang L,Jiang M,Yu Z

更新日期：2021-10-01 00:00:00

abstract：:Lymphomatosis cerebri (LC) is a significant challenge in terms of its clinical diagnosis due to it being a rare disease. The purpose of the present study was to investigate the multimodality imaging characteristics, clinical features and reasons for misdiagnosis of LC with the goal of potentially facilitating early an...

authors： Ruan Z,Chu L,Liu C,Hu Y,Huang J

更新日期：2021-10-01 00:00:00

abstract：:Periodontitis has been associated with many systemic diseases and conditions, including metabolic syndrome. Metabolic syndrome is a cluster of conditions that occur concomitantly and together they increase the risk of cardiovascular disease and double the risk of type 2 diabetes. In this review, we focus on the associ...

authors： Pirih FQ,Monajemzadeh S,Singh N,Sinacola RS,Shin JM,Chen T,Fenno JC,Kamarajan P,Rickard AH,Travan S,Paster BJ,Kapila Y

更新日期：2021-10-01 00:00:00

abstract：Objectives:To establish predictive equations for peak torque of muscle groups with totally and partially preserved innervation in individuals with motor complete spinal cord injury (SCI), based on hand dynamometry and strength predictor variables. Methods:The cross-sectional study conducted at a rehabilitation hospita...

authors： Neto FR,Dorneles JR,Carneiro Leão Veloso JH,Gonçalves CW,Gomes Costa RR

更新日期：2021-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Skull base osteomyelitis (SBO) is a challenging entity to diagnose and treat. The goal of this review is to summarize the imaging findings of SBO and present these in the context of recent studies on imaging of SBO. RECENT FINDINGS:This review discusses the clinical presentation, pathophysiology and ...

authors： Singhal A,Sotoudeh H,Chapman PR

更新日期：2021-10-01 00:00:00

abstract：:Colorectal cancer is a common malignant tumor of the gastrointestinal tract. Currently, the main treatment is surgical resection, which can be combined with other treatments. However, treatment efficacy is poor, and colorectal cancer is prone to relapse and metastasis; thus, identifying an effective anti-cancer drug i...

authors： Hu F,Wu Y,Liu C,Zhu Y,Ye S,Xi Y,Cui W,Bu S

更新日期：2021-10-01 00:00:00

abstract：:People with eating disorders suffer from a mental disorder that negatively affects their physical and/or mental health. The three most frequent eating disorders are binge eating disorder, bulimia nervosa, and anorexia nervosa. Environmental and genetic factors are involved in the pathogenesis of eating disorders in vu...

authors： Rangé H,Colon P,Godart N,Kapila Y,Bouchard P

更新日期：2021-10-01 00:00:00

abstract：:People use a particulate respirator in order to reduce exposure to ambient fine particulate matter (PM2.5). Acute exposure to PM2.5 is known to increase blood pressure. However, systematic reviews or meta-analyses on blood pressure-related benefits of using a particulate respirator is lacking. Therefore, we reviewed r...

authors： Han C,Lim YH,Hong YC

更新日期：2021-10-01 00:00:00

abstract：:Human papillomavirus (HPV) causes the majority of oropharyngeal, cervical, and anal cancers, among others. These HPV-associated cancers cause substantial morbidity and mortality despite ongoing vaccination efforts. Aside from the earliest stage tumors, chemoradiation is used to treat most HPV-associated cancers across...

authors： Sud S,Weiner AA,Wang AZ,Gupta GP,Shen CJ

更新日期：2021-10-01 00:00:00

abstract：:Spodoptera frugiperda is an important pest of several crops. Use of chemical insecticides in insect control has not been successful. In the present study, bio-nano formulation of bimetallic nanoparticles were synthesized using fungal metabolites from Metarhizium anisopliae and tested for insecticidal activity. Metarhi...

authors： Kumaravel J,Lalitha K,Arunthirumeni M,Shivakumar MS

更新日期：2021-10-01 00:00:00

abstract：:Environmental contaminants affect ecosystems worldwide and have deleterious effects on biota. Non-essential mercury (Hg) and lead (Pb) concentrations are well documented in some taxa and are described to cause multiple detrimental effects on human and wildlife. Additionally, essential selenium (Se) is known to be toxi...

authors： Lemaire J,Bustamante P,Mangione R,Marquis O,Churlaud C,Brault-Favrou M,Parenteau C,Brischoux F

更新日期：2021-10-01 00:00:00

abstract：:Hypertensive cardiac remodeling is illustrated by increased left ventricular (LV) mass index values and/or relative wall thickness (RWT) values >0.42, and functionally by isolated alteration of LV diastole (abnormal relaxation). The aim of the present study was to establish differentiated models of anatomical and func...

authors： Mocan O,Rădulescu D,Buzdugan E,Cozma A,Leucuta DC,Bogdan SA,Procopciuc LM

更新日期：2021-10-01 00:00:00

abstract：:Endoplasmic reticulum stress (ERS) and autophagy are important pathways, which induce apoptosis of tumor cells. Osthole has been demonstrated to exert anticancer effects via the induction of apoptosis in several human colon cancer lines, but the mechanism underlying its involvement in the induction of ERS and autophag...

authors： Zhou XH,Kang J,Zhong ZD,Cheng Y

更新日期：2021-10-01 00:00:00

abstract：SUMMARY:Critical access hospitals (CAHs) serve their rural communities as the main access points and communication centers for healthcare, typically with very limited financial, staffing, and support resources. Local residents rely on their CAHs as the only providers for many miles around. When the COVID-19 pandemic hi...

authors： Schou PM

更新日期：2021-10-01 00:00:00

abstract：:Cell therapy is a promising treatment strategy for patients with type 1 diabetes. Porcine pancreas‑derived mesenchymal stromal cells (PMSCs) have emerged as one of the most widely used cell resources owing to their high proliferative capacity and multi‑lineage differentiation potential. Although the induction efficien...

authors： Zhang S,Wang Q,Ji H,Lu H,Yang Q,Yin J,Guan W

更新日期：2021-10-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMCs) serve a decisive role in intimal hyperplasia, a common pathophysiological process that leads to numerous vascular disorders. The present study aimed to investigate the unknown mechanisms underlying VSMC phenotypic modulation and identified a novel microRNA (miRNA/miR)‑17‑5p/homeobo...

authors： Yu T,Wang T,Kuang S,Zhao G,Zhou K,Zhang H

更新日期：2021-10-01 00:00:00

abstract：:This article represents the point of view and philosophy of GSR Institute of Craniomaxillofacial and Facial Plastic Surgery (GSRIFCS) in the management of craniofacial and cleft patients. GSRICFS is a 50 bedded state of art high volume cleft centre in Hyderabad which has accomplished greater than 30000 cleft surgeries...

authors： Reddy SG,Pandey A,Bansal A

更新日期：2021-10-01 00:00:00

abstract：:Blocking the expression of programmed cell death ligand 1 (PD-L1) is a promising approach for the treatment of colon cancer. The binding of PD-L1 to its receptor programmed cell death 1 (PD-1) on immune cells leads to the apoptosis of activated T cells and causes immune escape. However, there is a limited number of pa...

authors： Xi X,Hu R,Wang Q,Xu K,Yang H,Cui Z,Zhang Y,Teng M,Xia L,Chen J,Liu Y

更新日期：2021-10-01 00:00:00

abstract：:Breast cancer manifests in diverse forms, with particular reference to various cell types harboring different mutations and gene expression profiles. To elucidate the clonal relationship between cancer cells in tumors composed of both ductal and lobular phenotypes, two combined lobular and ductal carcinoma (CLDC) case...

authors： Kobayashi H,Nakai T,Nakanishi Y,Esumi M,Masuda S

更新日期：2021-10-01 00:00:00

abstract：...

authors： Zhang Y,Yang X,Wu H,Zhou W,Liu Z

更新日期：2021-10-01 00:00:00

abstract：:Polygala japonica Houtt. (PJ), a member of the Polygala L. family that is suggested to exhibit detoxification properties in traditional Chinese medicine, is often used to treat upper respiratory tract infections. The anti-inflammatory effects of four main components of PJ (POL, PS-XLIX, PS-E, and PS-F) were examined u...

authors： Wu Y,Fu H,Yang X,Leng F,Huang Y,Deng H,Xiang Q,Zhang S

更新日期：2021-10-01 00:00:00

abstract：:Recruitment of lymphocytes to the vascular wall contributes to the pathogenesis of atherosclerosis (AS). The expression of cellular adhesion molecules, such as vascular cell adhesion molecule‑1 and intercellular adhesion molecule‑1, serves a critical role in mediating lymphocyte adhesion to the vascular wall. Choleste...

authors： Liu Q,Yang M,Zhang L,Zhang R,Huang X,Wang X,Du W,Hou J

更新日期：2021-10-01 00:00:00

abstract：:Pirarubicin (THP), one of the anthracycline anticancer drugs, is widely used in the treatment of various types of cancer, but its cardiotoxicity cannot be ignored. Canagliflozin, the first sodium‑glucose co‑transporter‑2 inhibitor approved by the USA FDA, has been shown to have a significant effect on cardiovascular d...

authors： Shi H,Zeng Q,Wei Y,Yang H,Tang H,Wang D,Pu P,Feng R

更新日期：2021-10-01 00:00:00

abstract：:Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell apoptotic assay data shown in Figs. 2C and 4B were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in...

authors： He J,Tang Y,Tian Y

更新日期：2021-10-01 00:00:00

abstract：:Studies have shown silver nanoparticles (AgNPs) exposure can result in a series of toxic effects in fish gills. However, it is still unclear how AgNPs affect metabolite expression and their related molecular metabolic pathways in fish gills. In this study, we employed untargeted metabolomics to study the effects of Ag...

authors： Li QQ,Xiang QQ,Lian LH,Chen ZY,Luo X,Ding CZ,Chen LQ

更新日期：2021-10-01 00:00:00

abstract：:The aim of this work was to study the thermogravimetric analysis through the pyrolysis of almond (Prunus amygdalus) shells for evaluating its potential for bioenergy at different heating rates (10, 25, and 50 K min-1). The activation energy values for the process were of the range of 153.0, 152.02, and 152.73 kJ mol-1...

authors： Rasool T,Najar I,Srivastava VC,Pandey A

更新日期：2021-10-01 00:00:00

abstract：BACKGROUND:To help inform the development of more accessible, acceptable, and effective ethics consultation (EC) training programs, we conducted an EC training needs assessment, exploring ethics practitioners' opinions on: the relative importance of various EC practitioner competencies; the potential market for EC trai...

authors： Fox E,Tarzian AJ,Danis M,Duke CC

更新日期：2021-10-01 00:00:00

abstract：:Microbial anodes and oxygen reducing microbial cathodes were designed separately under constant polarization at + 0.1 V/SCE in a hypersaline medium (NaCl 45 g/L). They were then associated to design two-compartment microbial fuel cells (MFCs). These MFCs produced up to 209 ± 24 mW m-2 during a week. This was the first...

authors： Rimboud M,Etcheverry L,Barakat M,Achouak W,Bergel A,Délia ML

更新日期：2021-10-01 00:00:00

abstract：:The photoautotrophic poly(3-hydroxybutyrate) (PHB) production by cyanobacteria is an attractive option as it only requires CO2 and light. In this work, a new wild-type strain producing PHB, Synechococcus elongatus UAM-C/S03, was identified using a polyphasic approach. The strain was cultured in a photobioreactor opera...

authors： González-Resendiz L,Sánchez-García L,Hernández-Martínez I,Vigueras-Ramírez G,Jiménez-García LF,Lara-Martínez R,Morales-Ibarría M

更新日期：2021-10-01 00:00:00

abstract：:A Saccharomyces cerevisiae strain CCW12OE was constructed by overexpressing CCW12 in a previously reported strain WXY70 harboring six xylose utilization genes. CCW12OE produced an optimal ethanol yield of 98.8% theoretical value within 48 h in a simulated corn stover hydrolysate. CCW12OEwas comprehensively evaluated f...

authors： Kong M,Li X,Li T,Zhao X,Jin M,Zhou X,Gu H,Mrša V,Xiao W,Cao L

更新日期：2021-10-01 00:00:00

abstract：:This paper proposed a novel method for modification of dolomite (Do) using the leaching solution derived from the spent ternary LIBs. During catalytic pyrolysis of biomass, the modified Do showed a good performance on both reducing the activation energy and upgrading the volatile products. The apparent activation ener...

authors： Wang P,Chen L,Shen Y

更新日期：2021-10-01 00:00:00

abstract：:With the outbreak of coronavirus pandemic the use of Hydroxychloroquine increased. These compounds have harmful effects on the environment, such as generation of antibiotic-resistant bacteria; therefore, their degradation has been considered as one of the environmental challenges. The purpose of this research is to sy...

authors： Kargar F,Bemani A,Sayadi MH,Ahmadpour N

更新日期：2021-10-01 00:00:00

abstract：:Amylose‑sodium stearate (SS) complexes (2, 5 and 8%) in heat-moisture treated potato starch (HPS) were evaluated for their physicochemical properties. Based on the DSC thermograms, the amylose - SS complexes were successfully formed with high thermal stability, indicated by a melt temperature (Tpeak) of ≥ 112 °C for t...

authors： Yassaroh Y,Nurhaini FF,Woortman AJJ,Loos K

更新日期：2021-10-01 00:00:00

abstract：:A pot experiment was conducted to explore the effects of high-quality (Huanghuazhan, HH), drought-resistant (IR, IRAT109) and drought-susceptible cultivars (ZS, Zhenshan97) under flooding irrigation and dry cultivation (D) on the starch accumulation and synthesis, physicochemical traits of starch granules and rice gra...

authors： Chen Z,Li P,Du Y,Jiang Y,Cai M,Cao C

更新日期：2021-10-01 00:00:00

abstract：:Amphipathic starch (AS) with hydrophobic octenylsuccinate (OS) and hydrophilic carboxymethyl (CM) substituents was prepared by the carboxymethylation and octenylsuccinylation of starch for strong bonding to fiber and easy removal from sized yarn. Two series of AS derivatives with differential degrees of substitution (...

authors： Zhu Z,Song Y,Xu Z,Li W,Zhang C

更新日期：2021-10-01 00:00:00

abstract：:Curdlan is a bacterial sourced polysaccharide, consisting of a linear backbone of β-1 → 3-linked glucose (Glc) units. The high interest in pharmaceutical applications of curdlan and derivatives thereof is fueling the study of multi-step sequences for regioselective modifications of its structure. Here we have develope...

authors： Vessella G,Esposito F,Traboni S,Di Meo C,Iadonisi A,Schiraldi C,Bedini E

更新日期：2021-10-01 00:00:00